Šta sve liči na depresiju, a nije?

Depresija spada u najčešće dijagnostikovane psihijatrijske poremećaje. Statistike iz SAD-a pokazuju da jedan od šest Amerikanaca tokom života iskuse bar jednu depresivnu epizodu, čiji intenzitet može da varira od veoma blagog do teškog. Prema predviđanjima stručnjaka Svetske zdravstvene organizacije, do 2020. godine, depresija će postati drugi najčešći uzrok nesposobnosti na svetu, premašivši po učestalosti i kardiovaskularne bolesti.

Malo ko neće umeti da prepozna gubitak samopouzdanja, „crne misli“, manjak interesovanja za seks, loše raspoloženje, bezvoljnost, stalnu iscrpljenost kao znakove depresije. Ono o čemu se ređe govori, to je da ovi simptomi ne moraju biti isključivo pokazatelj depresije; štaviše, simptomi koje razumemo kao depresiju uopšte ne moraju biti znak psihijatrijskog poremećaja. Postoje različite somatske bolesti koje se isprva mogu manifestovati nekim simptomima i znacima depresije. Continue reading

Novija istraživanja o efikasnosti antidepresiva

U proteklih nekoliko godina mediji sve češće dovode u pitanje delotvornost antidepresiva u lečenju depresije. Britanski independent objavio je skoro analizu stavova medija prema ovoj vrsti lekova, u saradnji sa članovima velike organizacije Rethink Mental Illness. Sve češće se i kod nas govori o “epidemiji prepisivanja lekova”, o “šokantnom porastu upotrebe antidepresiva”, i sl. Iza ovih stavova leži pretpostavka da je propisivanje antidepresiva po sebi nužno loša stvar.

Premda je 2008. objavljena dosta puta citirana i pominjana studija kojom je dovedeno u pitanje efikasnost fluoksetina (Flunirin) i još tri antidepresiva iz ove klase, većina istraživanja koja se objavljuju ipak ne daju ovakve rezultate. Ovde ćemo predstaviti nekoliko skoro objavljenih studija koje pokazuju da i noviji i stariji antidepresivi pokazuju zadovoljavajuću efikasnost i u smanjenju simptoma depresije i u sprečavanju novih depresivnih epizoda. Continue reading

Jastogom protiv anksioznosti

Omega-3 masne kiseline spadaju u grupu nezasićenih masnih kiselina o čijim se povoljnim efektima poslednjih godina dosta govori. Bogati izvori ovih kiselina mogu se naći u raznolikoj morskoj hrani, posebno u mesu jastoga. Postoje dokazi koji pokazuju da utiču na sniženje nivoa holesterola i triglicerida, istražuje se njihovo antikancersko dejstvo. Istraživanja efekata omega-3 masnih kiselina na simptome psihijatrijskih poremećaja dala su do sada raznolike i neretko kontradiktorne rezultate.

Istraživači sa Državnog univerziteta u Ohaju sproveli su duplo-slepo randomizovano ispitivanje efekata ovih kiselina na simptome depresije i anksioznosti kod studenata medicine, kao i nivoe citokina, markera zapaljenja, za koje se smatra da su povišeni onda kada opadne nivo omega-3 masnih kiselina u krvi. Kako bi testirali ovu hipotezu, uzimali su uzorke krvi kod studenata u ispitnom roku i u periodima kada nisu imali ispite. Od početka studije, studenti su redovno uzimali ili placebo ili 2.5g omega-3 masnih kiselina dnevno.

Statistička analiza pokazala je da porast omega-3 masnih kiselina u krvi utiče na sniženje anksioznosti kod studenata medicine kojima nije postavljana zvanična dijagnoza “anksioznog poremećaja”, kao i da opadaju koncentracije markera zapaljenja, kao što su TNF (faktor nekroze tumora) i interleukin 6. Ovo istraživanje, međutim, nije potvrdilo polaznu pretpostavku da omega-3 masne kiseline utiču i na poboljašanje simptoma depresivnosti.

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Mozak depresivnih osoba ne uspeva da se odmori

Izvor: La Repubblica.it

Istraživanje lekara Medicinskog fakulteta u Beču pokazalo je da u mozgu osoba sa depresijom postoje poteškoće u aktivnosti receptora čija je funkcija povezana sa postizanjem stanja relaksiranosti. Radi se o osećaju smirenosti koji imamo u situacijama kada nemamo ništa da radimo. U tim trenucima, mozak se odmara i „luta“. Ukoliko ne uspemo da postignemo ovo stanje, postajemo napeti.

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